Adding plans allows you to compare formulary status to other drugs in the same class. Contraindicated (1)phenelzine increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)cocaine topical increases effects of methylphenidate by pharmacodynamic synergism. Risk of V tach, HTN. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Contraindicated. Contraindicated. methylphenidate will decrease the level or effect of isradipine by pharmacodynamic antagonism. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. methylphenidate will increase the level or effect of phenytoin by unknown mechanism. Additive pressor effect. Potential for additive CNS stimulation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor. Monitor BP. Use Caution/Monitor. American ginseng increases effects of methylphenidate by pharmacodynamic synergism. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Methylphenidate is also the drug that manufacturers use in Ritalin. A Patient Handout is not currently available for this monograph. only. Most Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. esketamine intranasal, methylphenidate. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)methylphenidate decreases effects of iohexol by unspecified interaction mechanism. Modify Therapy/Monitor Closely. Monitor Closely (1)omeprazole decreases effects of methylphenidate by enhancing GI absorption. Risk of acute hypertensive episode. Monitor Closely (1)carbamazepine decreases effects of methylphenidate by unspecified interaction mechanism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Risk of acute hypertensive episode. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Methylphenidate may diminish antihypertensive effects. Monitor BP. Use Caution/Monitor. methylphenidate will decrease the level or effect of felodipine by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will decrease the level or effect of losartan by pharmacodynamic antagonism. Monitor BP. Avoid or Use Alternate Drug. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Risk of acute hypertensive episode. Use Caution/Monitor. Contraindicated. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. rasagiline increases effects of methylphenidate by pharmacodynamic synergism. Risk of acute hypertensive episode. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Monitor BP. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)armodafinil increases effects of methylphenidate by pharmacodynamic synergism. Risk of acute hypertensive episode. Caffeine should be avoided or used cautiously. methylphenidate and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)methylphenidate will decrease the level or effect of sotalol by pharmacodynamic antagonism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. iloperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. Monitor BP. epinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Risk of acute hypertensive episode. Use Caution/Monitor. Use Caution/Monitor. Contraindicated. Contact the applicable plan Use Caution/Monitor. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)epinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Dosage Conversions of Various Methylphenidate Formulations Table 3. Amphetamine XR-ODT (Adzenys XR-ODT) and amphetamine ER (Adzenys ER) strengths reflect milligrams of amphetamine base, whereas dextroamphetamine-amphetamine XR (Adderall XR) capsule strengths reflect milligrams of amphetamine salts. only. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)risperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. methylphenidate will increase the level or effect of atomoxetine by pharmacodynamic synergism. Use Caution/Monitor. Potential for additive CNS stimulation. caffeine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Applies only to oral form of both agents. Risk of acute hypertensive episode. Adults20 to 30 milligrams (mg) given in divided doses 2 or 3 times a day, taken 30 to 45 minutes before meals. Monitor for hypertension with concomitant use. Methylphenidate may diminish antihypertensive effects. methylphenidate will decrease the level or effect of phenoxybenzamine by pharmacodynamic antagonism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Mechanism: unknown. Dosing (usual): Treatment of ADHD in children and adolescents up to 70 kg body weight. Monitor Closely (1)ephedrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Monitor BP. Use Caution/Monitor. Monitor BP. Use Caution/Monitor. Applies only to oral form of both agents. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Use Caution/Monitor. Are Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Significantly Linked to Childhood Allergies? Applies only to oral form of both agents. Monitor Closely (1)trimipramine, methylphenidate. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of fosinopril by pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of nimodipine by pharmacodynamic antagonism. Either increases effects of the other by serotonin levels. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Mechanism: pharmacodynamic synergism. Contraindicated. epinephrine racemic and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. bromocriptine, methylphenidate. Additive vasospasm; risk of hypertension. Use Caution/Monitor. Contraindicated. Methylphenidate may diminish antihypertensive effects. informational and educational purposes only. Interaction more likely in certain predisposed pts. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Serious - Use Alternative (1)lofepramine, methylphenidate. Applies only to oral form of both agents. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Potential for additive CNS stimulation. Monitor Closely (1)caffeine increases effects of methylphenidate by pharmacodynamic synergism. Individual plans may vary Monitor Closely (1)methylphenidate increases effects of warfarin by unspecified interaction mechanism. The above information is provided for general Monitor Closely (1)molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. thioridazine, methylphenidate. amantadine, methylphenidate. Methylphenidate may diminish antihypertensive effects. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. In general, administer drugs at least 2 hr before or after sodium zirconium cyclosilicate. Mechanism: unknown. Use Caution/Monitor. Monitor Closely (1)aripiprazole increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Use Caution/Monitor. Interaction specifically associated with Ritalin LA. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Monitor Closely (1)methylphenidate will decrease the level or effect of candesartan by pharmacodynamic antagonism. Applies only to oral form of both agents. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Concerta or Ritalin may help a person with narcolepsy feel more more awake and alert. Contraindicated. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. The recommended dose of CONCERTA for patients who are currently taking methylphenidate twice daily or three times daily at doses of 10 to 60 mg/day is provided in Table 2. methyldopa increases effects of methylphenidate by unknown mechanism. Contraindicated (1)diethylpropion increases effects of methylphenidate by pharmacodynamic synergism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. , more likely w/thioridazine than other phenothiazines an MAOI and also within a minimum of 14 days following of... Epinephrine racemic and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate Attention-Deficit/Hyperactivity. Toxicity of methylphenidate by pharmacodynamic antagonism monitor blood pressure and heart rate administer drugs at least 5 before! 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